The question of whether Wacom Cintiq 16 or 22 really boils down to the size of drawing area you want.
Pressure sensitivity (8,192 levels) and tilt recognition (±60 degrees) are the same, as both tablet use Wacom’s industry-leading Pro Pen 2.
Neither of the drawing tablets has built-in hotkeys and a touch screen. If you like to work with a set of programmable buttons, you’ll need to purchase the optional ExpressKey Remote for both the Cintiq 16 and 22.
What is different in terms of Wacom Cintiq 22 vs 16 are the supplied stand and the type of cable connections.
The Cintiq 22 arrives with Wacom’s adjustable tilt stand that lets you choose a working angle between 16 and 82 degrees. The Cintiq 16, on the other hand, comes only with fold-out legs for a fixed 19-degree angle. If you want more flexibility, you have to purchase a separate stand.
That said, the Cintiq 16 has a more practical and less tangly 3-in-1 cable connection. That means you’ll only have one cable coming from the Cintiq 16’s top, which branches into HDMI 1.4, USB 2.0, and AC adapter.
The Cintiq 22, however, needs three individual cables plugged in: HDMI, USB 2.0, and AC adapter. This can be an advantage or disadvantage. An all-in-one connection surely causes less cable clutter on your desk, but if one of the cables breaks, you only need to replace the broken one on the Cintiq 22.
→ Read our full Wacom Cintiq 16 Review for more.